Evaluation of changes in retinal and peripapillary microvasculature in patients with macula-on rhegmatogenous retinal detachment treated with silicon oil using optical coherence tomography angiography
Mohammad reza Ansari Astaneh1 *, Seyed Abdolali Aghili1 , Hmidreza Heidarzadeh1
- Eye research center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract: To investigate changes in optical coherence tomography angiography (OCT-A) parameters of optic nerve, macula and choroidal thickness before and during intervals after vitrectomy procedures with silicone oil (SO) in patients with macula-on rhegmatogenous retinal detachment (RRD).
Methods: This study conducted on 2021.Sixteen patients with macula-on RRD who were referred to Khatam Al Anbia Hospital of Mashhad, Iran, were enrolled. Patients underwent OCT-A and enhanced depth imaging (EDI) OCT before and after vitrectomy with silicone oil. The superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD), the foveal avascular zone (FAZ), The radial peripapillary capillary (RPC) vessel density and choroidal and macular thickness was measured. Statistical analysis performed using SPSS software version 22.
Results: The FAZ area was increased significantly at month 3 after SO tamponade than preoperative (0.23± 0.08 vs. 0.26± 0.07, P=0.001). The SCP VD in whole image was significantly lower at month 1 (47.65± 2.16) and month 3 (46.62± 2.14) than preoperative (48.43± 2.17) (P<0.001, for both). The foveal VD in DCP decreased significantly at month 1 and 3 after SO tamponade (P<0.001). A significant reduction was observed in parafoveal VD in both SCP and DCP at month 1 and 3 compared to preoperative (P<0.001). The RPC VD decreased significantly after SO tamponade (P<0.001). The choroidal thickness at month 1 and 3 was significantly lower than preoperative (P<0.001). No significant differences were recorded in macular thickness at month 1 (P=1.00), while it increased significantly at month 3 after surgery (P<0.001).
Conclusion: Significant retinal microvascular changes were detected despite successful retinal reattachment in patients with macula-on RRD. The duration of using SO tamponade might be a factor for change in the retinal and peripapillary vascular changes.
