Secondary Corneal Keloid: Report of Two Cases
Amin Zand1 *, Ali Sharifi1 , Touraj-Reza Mirshekari2 , Milad Azh1 , Hamid Sadeghi1
- 1. Department of Ophthalmology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran
- 2. Department of Pathology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran
Abstract: This study aims to present the clinicopathological characteristics and surgical outcomes of two cases involving secondary corneal keloids following ocular surface trauma and surgery.
Methods: We conducted clinical and histological evaluations on two male patients who presented with slowly-growing, pearly white nodules on the cornea. One patient had a history of corneal trauma due to contact with boiling sunflower oil, while the other had undergone pterygium removal. Upon slit lamp examination, the corneal lesions were identified as single, well-circumscribed, pearly white nodules with a smooth surface. We successfully removed these nodules using a combination of superficial keratectomy and the application of mitomycin C.
Results: Light microscopy analysis of the excised nodules revealed hyperplastic epithelium, disrupted Bowman's layer, and irregularly arranged abundant collagen fibers within the stroma. Therefore, the diagnosis of corneal keloid was established for both of them. Notably, there was no recurrence of the lesions in either case within six months following the surgical excision.
Conclusion: Secondary corneal keloids should be considered as a potential diagnosis in patients with elevated corneal nodules, especially when there is a history of ocular surface trauma or surgery. Given the risk of recurrence, it is imperative to ensure long-term follow-up for these patients.
