Levator palpebralis superioris muscle histopathologic findings in congenital ptosis and surgical outcome after its resection: Is there any association?
Mansoreh Jamshidian Tehrani1 *
- Ophthalmic
Plastic and Reconstructive Surgery Unit, Eye ResearchCenter, Farabi Eye
Hospital, Tehran University of Medical Sciences, Qazvin Square, Tehran
Abstract: To evaluate the histopathologic findings of Levator palpebralis superioris (LPS) muscle biopsy after LPS resection for
treatment of congenital ptosis and its possible relation with surgical outcomes.
Methods: Congenital ptosis patients were enrolled in this retrospective study. All of them underwent full ophthalmologic examination
included of Margin-reflex distance 1 (MRD-1) and LPS function measurement preoperatively. The patients were followed for
three months for the postoperative period and after that the measurements were repeated. Histologic parameters including
percentages of fat, striated and smooth muscle, and fibrous tissue. The histopathologic findings and their possible correlation
with the measurements are analyzed.
Results: 67 patients with unilateral congenital ptosis were enrolled. 45 patients (67.2%) were males. The mean age of patients was
16.10 ± 11.18 years. The patients’ MRD-1 was improved significantly from 0.82 ± 1.26 mm to 3.85 ± 1.25 mm after LPS
resection (P = 0.000). The success rate was 80.3%. There were no correlations between MRD change and histopathologic
tissue percentages but significant correlation was found between success of surgery and fibrous tissue percentage of resected
sample (P = 0.033).
Conclusion: The histopathology of the LPS may be useful in prediction of surgical outcome after LPS resection in congenital ptosis
patients. The percentage of fibrous tissue play an important role.
