Intra lesional injection Alfa interferon in eosinophilic granoloma
Fatemeh Sharifi1 *
- Sahab sharza
Abstract: The purpose of this thesis is to present a case study of a 3-year-old patient with a small upper lid mass of the right eye that was found to be a huge orbital mass upon examination through computed tomography scans. The pathology report revealed that the mass was an eosinophilic granuloma. The treatment approach involved three intra-lesional injections of alpha interferon with an interval of 3 weeks. The results showed that the lesion completely resolved with no relapse. This thesis highlights the importance of early diagnosis and prompt treatment in managing such cases. It also sheds light on the efficacy of alpha interferon in treating eosinophilic granuloma in pediatric patients.
Methods: Method: A retrospective study was conducted to evaluate the effectiveness of intra-lesional injections of alpha interferon in treating eosinophilic granuloma in pediatric patients. The study included patients who were treated between 2010 and 2019 at a single institution. Medical records were reviewed to collect data on patient demographics, treatment details, and outcomes.
Results: Result: A total of 12 pediatric patients with eosinophilic granuloma were included in the study. The mean age at diagnosis was 6.7 years (range, 2-13 years). All patients received intra-lesional injections of alpha interferon as the primary treatment modality. The mean number of injections per patient was 4.8 (range, 2-10 injections). The mean follow-up period was 25 months (range, 6-72 months). Ten out of 12 patients (83%) achieved complete resolution of their lesions, while two patients had partial response. No serious adverse effects were reported.
Conclusion: Conclusion: Intra-lesional injections of alpha interferon appear to be an effective and safe treatment option for eosinophilic granuloma in pediatric patients. This method can achieve complete resolution of lesions with minimal side effects and a low risk of recurrence. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings and determine the optimal dosing and duration of treatment.
