Association between serum uric acid level and glaucoma: a systematic review and meta-analysis
Mohammad Mohammadi1 *, Hamed Ghoshouni1 , Amin Salehi-Abargoei2
- School of Medicine, Shahid Sadoughi University of Medical Sciences
- School of Public Health, Shahid Sadoughi University of Medical Sciences
Abstract: Glaucoma, the leading cause of irreversible blindness, is a common disorder that contributes to gradual optic nerve degeneration. The beneficial impacts of uric acid (UA) have been reported in some neurodegenerative conditions such as Parkinson's disease, Alzheimer’s disease, and amyotrophic lateral sclerosis. But the results of current studies about association between serum UA level and glaucoma are conflicting. The present meta-analysis was conducted to provide a better understanding of the association between serum UA level and glaucoma.
Methods: We searched the databases of PubMed, Scopus, Web of Science, and the Google Scholar systematically until November 20, 2022 to identify case-control studies, comparing the serum UA concentration of the patients with glaucoma and controls. The mean ± standard division difference was used to assess the difference in serum UA concentrations between the glaucoma patients and controls.
Results: Six studies involving 1221 glaucoma patients and 1342 control group were included in present meta-analysis. This meta-analysis using a random effect model indicated that the mean UA level in glaucoma patients was 0.16 (I2=95.56%, 95%CI= -0.57 – 0.89) higher than the controls; however, it was not statistically significant.
Conclusion: Our findings provide evidence that glaucoma patients have a higher serum UA level compared to the controls, but this difference is not statistically significant.
